![]() He initiated and maintained a successful cooperation with the bone marrow transplant unit since the early 70s and participated in the design of protocols related to stem cell transplantation for patients with SCID, Wiskott-Aldrich Syndrome, GGD, and Hyper IgM Syndrome. In 1995, he moved the immunodeficiency clinic from the University to Children's Hospital, providing diagnostic evaluations and clinical care for both pediatric and adult patients with PIDD. Recently, he focused on the gene Uracil-DNA Glycosulase, causing a rare form of autosomal recessive hyper IgM syndrome and on STAT3, the gene causing autosomal dominant Hyper IgE Syndrome if mutated. He and his collaborators contributed to the identification of several genes associated with PIDD located on the X chromosome, including CD40L, Wiskott-Aldrich Syndrome protein, BTK, and FOXP3. Ochs' clinical interests focus on the use of intravenous and subcutaneous immunoglobulin and the in vivo analysis of antibody production using Bacteriophage FX174. To improve the long-term outcome of these disorders, he has actively participated in clinical trials to develop immunoglobulin replacement, hematopoietic stem cell transplantation, and gene therapy.ĭr. Ochs' research focuses on the molecular basis of Primary Immune Deficiency Diseases with special interest in the genes that have been linked to the Wiskott Aldrich Syndrome, Hyper IgM syndromes, X-linked Agammaglobulinemia, IPEX syndrome, autosomal recessive Hyper IgE syndrome. University of Washington School of Medicine, Seattle, WAĭr. He is principal editor for the medical textbook Primary Immunodeficiency Diseases: A Molecular and Genetic Approach and co-editor for Immunological Disorders in Infants and Children.Īlbert-Ludwigs Universitat Freiburg, D-79110 Freiburg Im Breisgau ![]() Immune Deficiency Network (USIDnet) and is co-founder and member of the summer school faculty devoted to primary immune deficiencies. He has initiated clinical trials for new immunoglobulin preparations for intravenous and subcutaneous infusions and has collaborated with the bone marrow transplant team in the design of new protocols for stem cell transplant and gene therapy. Ochs started the Immunodeficiency Clinic at Seattle Children’s in 1985, providing evaluation and care for both pediatric and adult patients with immunodeficiency disorders. ![]() He and his collaborators contributed significantly to the identification of a number of genes associated with PIDD located on the X chromosome (CD40L, Wiskott-Aldrich syndrome protein, FOXP3, gp91phox) or on autosomes (uracil-DNA glycosulase Rag1, Rag2 hypomorphic mutations as the cause of Omenn syndrome, STAT3 responsible for AD-HIES). ![]() The focus of his research is the molecular definition of primary immunodeficiency diseases (PIDD) and the investigation of new techniques to confirm the diagnosis. He completed his residency in pediatrics at the University of Washington. He earned his MD summa cum laude from the University of Freiburg, Germany. Ochs, MD, is attending physician at Seattle Children’s Hospital. Niranjan Kumar Sharma, MBBS, FRNZCGP, PhDĬathy M.Hans D. ![]() Khanagavi, MD, FACP, FACC, FSCAIĬhristina M. Please let us know if you are interested in mentoring others in the peer review process.Įditor's note: Dr. If you are interested in reviewing for AFP, please visit the Reviewers' Guide and complete a reviewer profile, or email us at For new reviewers, we highly recommend that you find a mentor for your first review. My hope is to continually improve our processes, enrich the skills of our current and future reviewers, and highlight more exceptional reviewers year after year. An archive of past AFP peer reviewers is available. Peer review continues to be an essential and valuable process for the journal, and we are very appreciative of the work reviewers do in helping us develop sound content for AFP. In addition to recognizing peer reviewers for volunteering their time, we continue to highlight reviewers who provided exceptional feedback and received a high rating on the reviews they provided to AFP authors and editors (listed in bold). Sexton, MD, Georgetown University Medical Center, Washington, District of Columbia Acknowledging and Thanking AFP's Peer Reviewers for 2022 ![]()
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